⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28482706 | 1.00 | — | — | |
| SCHEMBL855511 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL28083964 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL25259382 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL23698686 | 0.97 | — | — | |
| SCHEMBL16682005 | 0.76 | — | — | |
| SCHEMBL13346619 | 0.76 | — | — | |
| SCHEMBL7654847 | 0.76 | — | — | |
| SCHEMBL3638679 | 0.74 | — | — | |
| SCHEMBL6980025 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023104043-A1 | ANTI-APOPTOTIC PROTEIN BCL-2 INHIBITOR, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 杭州和正医药有限公司 | 2023-06-15 | — | — | WO | disclosed |
| CN-116217566-A | Anti-apoptosis protein BCL-2 inhibitor, pharmaceutical composition and application thereof | 杭州和正医药有限公司 | 2023-06-06 | — | — | CN | disclosed |
| CN-115490708-A | Sulfonamide macrocyclic derivatives, and preparation method and application thereof | 苏州亚盛药业有限公司 | 2022-12-20 | — | — | CN | disclosed |
| CN-115484933-A | Hot melt extrusion solid dispersions containing BCL2 inhibitors | 广州麓鹏制药有限公司 | 2022-12-16 | — | — | CN | disclosed |
| CN-109641897-B | Bcl-2 selective inhibitors, their preparation and use | 北京赛林泰医药技术有限公司 | 2021-12-07 | — | — | CN | disclosed |
| CN-107987075-B | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | 艾伯维公司 | 2020-12-01 | — | — | CN | disclosed |
| CN-109293656-A | Bcl-2 selective depressant and its preparation and use | 北京赛林泰医药技术有限公司 | 2019-02-01 | — | — | CN | disclosed |