Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.35 |
| ▸ | RELA | Q04206 | 2/20 | 0.35 |
| ▸ | BUB1 | O43683 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30398140 | 0.91 | KMT2A (0.43) | BTKKMT2AL3MBTL1KDM1AMAOB | |
| SCHEMBL21222073 | 0.86 | BACE1 (0.36) | HSD11B1 | |
| SCHEMBL21222072 | 0.86 | BACE1 (0.36) | HSD11B1 | |
| SCHEMBL22614223 | 0.86 | BACE1 (0.36) | HSD11B1 | |
| SCHEMBL5831941 | 0.84 | BACE1 (0.36) | L3MBTL1HSD11B1 | |
| SCHEMBL5831935 | 0.84 | BACE1 (0.36) | L3MBTL1HSD11B1 | |
| SCHEMBL14646990 | 0.84 | KDM1A (0.53) | BTKKMT2AL3MBTL1KDM1AMAOB | |
| SCHEMBL18581937 | 0.83 | KDM1A (0.42) | BTKKMT2AL3MBTL1KDM1AMAOB | |
| SCHEMBL2940110 | 0.80 | BTK (0.46) | BTKKMT2AL3MBTL1KDM1AMAOB | |
| SCHEMBL2940111 | 0.80 | BTK (0.46) | BTKKMT2AL3MBTL1KDM1AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |