Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 16/20 | 0.39 |
| ▸ | BTK | Q06187 | 2/20 | 0.36 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14630141 | 1.00 | TNK2 (0.39) | TNK2BTKPROKR1FGFR2 | |
| SCHEMBL27188443 | 0.94 | FGFR4 (0.39) | TNK2BTKFGFR2 | |
| SCHEMBL27188440 | 0.94 | FGFR4 (0.39) | TNK2BTKFGFR2 | |
| SCHEMBL18283348 | 0.87 | TNK2 (0.48) | TNK2BTKFGFR2 | |
| SCHEMBL28859036 | 0.87 | TNK2 (0.40) | TNK2BTKPROKR1FGFR2 | |
| SCHEMBL14631159 | 0.87 | TNK2 (0.48) | TNK2BTKFGFR2 | |
| SCHEMBL18345372 | 0.85 | TNK2 (0.51) | TNK2BTK | |
| SCHEMBL16748868 | 0.85 | TNK2 (0.51) | TNK2BTK | |
| SCHEMBL14630474 | 0.83 | TNK2 (0.47) | TNK2FGFR2 | |
| SCHEMBL400077 | 0.83 | TNK2 (0.46) | TNK2FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023110970-A1 | MACROCYCLIC BTK INHIBITORS | NETHERLANDS TRANSLATIONAL RESEARCH CENTER HOLDING B.V (NL) | 2023-06-22 | — | — | WO | disclosed |
| WO-2023110936-A1 | REVERSIBLE MACROCYCLIC KINASE INHIBITORS | NETHERLANDS TRANSLATIONAL RESEARCH CENTER HOLDING B.V (NL) | 2023-06-22 | — | — | WO | disclosed |
| CN-109851620-B | Fused bicyclic compounds for inhibiting tyrosine kinase activity | 深圳市塔吉瑞生物医药有限公司 | 2020-08-07 | — | — | CN | disclosed |