Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 14/20 | 0.51 |
| ▸ | EGLN2 | Q96KS0 | 6/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.48 |
| ▸ | VEGFA | P15692 | 3/20 | 0.46 |
| ▸ | FLT1 | P17948 | 3/20 | 0.46 |
| ▸ | EGLN3 | Q9H6Z9 | 2/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.46 |
| ▸ | TET3 | O43151 | 1/20 | 0.43 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.43 |
| ▸ | ASPH | Q12797 | 1/20 | 0.43 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.43 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.43 |
| ▸ | OGFOD1 | Q8N543 | 1/20 | 0.43 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.43 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25279944 | 0.89 | EGLN1 (0.50) | EGLN1EGLN2VEGFAFLT1EGLN3 | |
| SCHEMBL25232892 | 0.86 | EGLN1 (0.59) | EGLN1EGLN2VEGFAFLT1EGLN3 | |
| SCHEMBL30457430 | 0.86 | EGLN1 (0.59) | EGLN1EGLN2VEGFAFLT1EGLN3 | |
| SCHEMBL25274490 | 0.81 | EGLN1 (0.55) | EGLN1EGLN2VEGFAFLT1EGLN3 | |
| SCHEMBL30457510 | 0.81 | EGLN1 (0.55) | EGLN1EGLN2VEGFAFLT1EGLN3 | |
| SCHEMBL25233254 | 0.81 | EGLN2 (0.58) | EGLN1EGLN2VEGFAFLT1EGLN3 | |
| SCHEMBL25278878 | 0.81 | EGLN2 (0.53) | EGLN1EGLN2MRGPRX4VEGFAFLT1 | |
| SCHEMBL25234150 | 0.80 | EGLN2 (0.65) | EGLN1EGLN2VEGFAFLT1EGLN3 | |
| SCHEMBL25232900 | 0.79 | EGLN1 (0.63) | EGLN1EGLN2VEGFAFLT1EGLN3 | |
| SCHEMBL25276560 | 0.77 | EGLN2 (0.56) | EGLN1EGLN2VEGFAFLT1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4447963-A1 | SELECTIVE PHD1 INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | Akebia Therapeutics Inc. (US) | 2024-10-23 | — | — | EP | disclosed |
| US-20240336568-A1 | SELECTIVE PHD1 INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2024-10-10 | — | — | US | disclosed |
| WO-2023111990-A1 | SELECTIVE PHD1 INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2023-06-22 | — | — | WO | disclosed |
| WO-2023111990-A1 | SELECTIVE PHD1 INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2023-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240336568-A1 | SELECTIVE PHD1 INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | HIF1AN, EGLN1, EGLN2 | EGLN1 2/4885EGLN2 3/4885MRGPRX4 3370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.