Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 9/20 | 0.56 |
| ▸ | HTR6 | P50406 | 5/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25286345 | 0.92 | HTR2A (0.47) | HTR2AHTR6ARDYRK1ATAAR1 | |
| SCHEMBL25290621 | 0.85 | AR (0.46) | HTR2AARDYRK1AHTR2CTAAR1 | |
| SCHEMBL25246712 | 0.83 | HTR2A (0.63) | HTR2AARHTR2CHTR2B | |
| SCHEMBL31357926 | 0.83 | HTR2A (0.49) | HTR2AHTR6HTR2CHTR2B | |
| SCHEMBL25285910 | 0.80 | HTR2A (0.49) | HTR2AHTR6HTR2CHTR2B | |
| SCHEMBL25293469 | 0.80 | HTR2A (0.65) | HTR2AHTR6ARDYRK1AHTR2C | |
| SCHEMBL31358090 | 0.78 | HTR2A (0.60) | HTR2AHTR6AR | |
| SCHEMBL31358038 | 0.78 | HTR2A (0.53) | HTR2AHTR6HTR2CHTR2B | |
| SCHEMBL654975 | 0.77 | HTR2C (0.61) | HTR2AHTR6ARDYRK1AHTR2C | |
| SCHEMBL31295140 | 0.76 | HTR2A (0.65) | HTR2AHTR6HTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4447954-A1 | HETEROCYCLIC COMPOUNDS AS 5HT2A BIASED AGONISTS | Icahn School of Medicine at Mount Sinai (US) | 2024-10-23 | — | — | EP | disclosed |
| WO-2023114472-A1 | HETEROCYCLIC COMPOUNDS AS 5HT2A BIASED AGONISTS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2023-06-22 | — | — | WO | disclosed |
| WO-2023114472-A1 | HETEROCYCLIC COMPOUNDS AS 5HT2A BIASED AGONISTS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2023-06-22 | — | — | WO | disclosed |