Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 3/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | FYN | P06241 | 2/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1285052 | 0.79 | NPC1 (0.55) | NPC1MAPTMEN1KMT2AEGFR | |
| SCHEMBL16926443 | 0.75 | TYK2 (0.47) | POLBGAANPC1MAPTTYK2 | |
| SCHEMBL31247545 | 0.75 | EGFR (0.52) | NPC1TYK2EGFRERBB3JAK2 | |
| SCHEMBL12517775 | 0.74 | NPC1 (0.43) | GAANPC1TYK2MEN1KMT2A | |
| SCHEMBL25294012 | 0.73 | POLB (0.44) | POLBGAAMAPTTYK2AKR1C3 | |
| SCHEMBL25245407 | 0.73 | GRM5 (0.41) | POLBGAANPC1MAPTAKR1C3 | |
| SCHEMBL25282403 | 0.71 | GRM5 (0.43) | POLBGAAMAPTTYK2AKR1C3 | |
| SCHEMBL31247411 | 0.71 | NPC1 (0.50) | POLBNPC1MEN1KMT2ARAB9A | |
| SCHEMBL25293421 | 0.70 | GAA (0.53) | POLBGAANPC1MAPTTYK2 | |
| SCHEMBL20575194 | 0.70 | MEN1 (0.55) | NPC1TYK2MEN1KMT2AJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | disclosed |