Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 18/20 | 0.65 |
| ▸ | EGFR | P00533 | 15/20 | 0.55 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.42 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2518936 | 0.93 | ERBB2 (0.65) | ERBB2EGFRSPHK2SPHK1AURKA | |
| SCHEMBL1406311 | 0.91 | ERBB2 (0.77) | ERBB2EGFRAURKAAURKB | |
| SCHEMBL2516362 | 0.85 | ERBB2 (0.68) | ERBB2EGFR | |
| SCHEMBL1406701 | 0.83 | ERBB2 (0.77) | ERBB2EGFRAURKAAURKB | |
| SCHEMBL2542118 | 0.80 | ERBB2 (0.82) | ERBB2EGFR | |
| SCHEMBL5507894 | 0.79 | ERBB2 (0.83) | ERBB2EGFR | |
| SCHEMBL2515689 | 0.79 | ERBB2 (0.55) | ERBB2EGFR | |
| SCHEMBL2522164 | 0.79 | ERBB2 (0.69) | ERBB2EGFR | |
| SCHEMBL1406586 | 0.79 | ERBB2 (1.00) | ERBB2EGFR | |
| SCHEMBL1406327 | 0.78 | ERBB2 (0.85) | ERBB2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838712-B8 | PYRAZOLOPYRIMIDINE COMPOUNDS AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2011-10-12 | — | — | EP | claimed |
| EP-1838712-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AS ANTITUMOR AGENTS | AstraZeneca AB (SE) | 2007-10-03 | — | — | EP | claimed |
| WO-2006064196-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | claimed |
| EP-1838712-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AS ANTITUMOR AGENTS | AstraZeneca AB (SE) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006064196-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | disclosed |