⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25260428 | 0.78 | — | — | |
| SCHEMBL25234659 | 0.61 | — | — | |
| SCHEMBL10316967 | 0.47 | — | — | |
| SCHEMBL570870 | 0.34 | — | — | |
| SCHEMBL13719381 | 0.30 | — | — | |
| SCHEMBL25437025 | 0.24 | — | — | |
| SCHEMBL6559802 | 0.24 | — | — | |
| Selenium SCHEMBL10637726 | 0.24 | — | — | |
| SCHEMBL1652932 | 0.24 | — | — | |
| SCHEMBL278542 | 0.24 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230278984-A1 | UREA DERIVATIVES AS PYRUVATE KINASE ACTIVATORS | GLOBAL BLOOD THERAPEUTICS INC (US) | 2023-09-07 | — | — | US | disclosed |
| EP-4188542-A1 | UREA DERIVATIVES AS PYRUVATE KINASE ACTIVATORS | Global Blood Therapeutics, Inc. (US) | 2023-06-07 | — | — | EP | disclosed |