Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 2/20 | 0.32 |
| ▸ | INSR | P06213 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2509642 | 0.81 | ALK (0.44) | ALKINSRJAK2 | |
| SCHEMBL520863 | 0.75 | ALK (0.39) | ALKINSRJAK2 | |
| SCHEMBL521195 | 0.69 | ALK (0.42) | ALKINSRJAK2 | |
| SCHEMBL19221933 | 0.68 | FYN (0.41) | ALKINSRJAK2 | |
| SCHEMBL2523523 | 0.67 | ALK (0.36) | ALKINSRJAK2 | |
| SCHEMBL521079 | 0.66 | JAK2 (0.45) | JAK2 | |
| SCHEMBL520606 | 0.66 | ALK (0.55) | ALKINSRJAK2 | |
| SCHEMBL522170 | 0.66 | JAK2 (0.41) | ALKINSRJAK2 | |
| SCHEMBL521486 | 0.66 | JAK2 (0.39) | ALKINSRJAK2 | |
| SCHEMBL520259 | 0.66 | EGLN2 (0.40) | ALKINSRJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |