Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.53 |
| ▸ | JAK1 | P23458 | 18/20 | 0.53 |
| ▸ | TYK2 | P29597 | 18/20 | 0.53 |
| ▸ | JAK3 | P52333 | 18/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30586488 | 1.00 | JAK2 (0.53) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL30586467 | 0.85 | JAK2 (0.50) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL25303981 | 0.85 | JAK2 (0.50) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL30581408 | 0.84 | KMT2A (0.47) | KMT2A | |
| SCHEMBL19436506 | 0.83 | JAK2 (0.62) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL19436566 | 0.83 | JAK2 (0.62) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL19437496 | 0.81 | JAK2 (0.52) | JAK2JAK1TYK2JAK3KMT2A | |
| Nitrous Acid SCHEMBL25424540 | 0.81 | KMT2A (0.43) | KMT2A | |
| SCHEMBL19436490 | 0.81 | JAK2 (0.55) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL19437515 | 0.81 | KMT2A (0.63) | JAK2JAK1TYK2JAK3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116444544-A | Benzimidazole compound and medical application thereof | 中国科学院上海药物研究所 | 2023-07-18 | — | — | CN | disclosed |
| WO-2023131333-A1 | BENZIMIDAZOLE COMPOUND AND MEDICAL USE THEREOF | 中国科学院上海药物研究所 | 2023-07-13 | — | — | WO | disclosed |
| WO-2023131333-A1 | BENZIMIDAZOLE COMPOUND AND MEDICAL USE THEREOF | 中国科学院上海药物研究所 | 2023-07-13 | — | — | WO | disclosed |