Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 8/20 | 0.52 |
| ▸ | INSR | P06213 | 7/20 | 0.52 |
| ▸ | EGFR | P00533 | 3/20 | 0.52 |
| ▸ | JAK2 | O60674 | 10/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | NPM1 | P06748 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2523768 | 0.94 | ALK (0.52) | ALKINSREGFRJAK2CYP3A4 | |
| SCHEMBL2515163 | 0.86 | ALK (0.52) | ALKINSRJAK2CYP3A4NPM1 | |
| SCHEMBL521592 | 0.85 | JAK2 (0.64) | ALKINSREGFRJAK2CYP3A4 | |
| SCHEMBL521051 | 0.85 | ALK (0.61) | ALKINSREGFRJAK2CYP3A4 | |
| SCHEMBL2512691 | 0.84 | ALK (0.52) | ALKINSRJAK2CYP3A4NPM1 | |
| SCHEMBL16530423 | 0.83 | EGFR (0.49) | ALKINSREGFRJAK2CYP3A4 | |
| SCHEMBL2524303 | 0.82 | ALK (0.54) | ALKINSRJAK2CYP3A4 | |
| SCHEMBL521619 | 0.79 | ALK (0.61) | ALKINSRJAK2CYP3A4NPM1 | |
| SCHEMBL521996 | 0.79 | JAK2 (0.64) | ALKINSRJAK2CYP3A4NPM1 | |
| SCHEMBL521097 | 0.78 | JAK2 (0.63) | ALKINSREGFRJAK2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |