Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | IDE | P14735 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL252659 | 1.00 | MAPT (0.40) | MAPTNPSR1RECQLTDP1L3MBTL1 | |
| SCHEMBL8511185 | 0.96 | MAPT (0.40) | MAPTNPSR1RECQLTDP1L3MBTL1 | |
| SCHEMBL8511177 | 0.96 | MAPT (0.40) | MAPTNPSR1RECQLTDP1L3MBTL1 | |
| SCHEMBL8510897 | 0.93 | HPGD (0.38) | POLBHPGDMEN1KMT2APARP1 | |
| SCHEMBL8510894 | 0.93 | HPGD (0.38) | POLBHPGDMEN1KMT2APARP1 | |
| SCHEMBL8514555 | 0.90 | SOS1 (0.37) | MAPTNPSR1RECQLHPGDPARP1 | |
| SCHEMBL8514561 | 0.90 | SOS1 (0.37) | MAPTNPSR1RECQLHPGDPARP1 | |
| SCHEMBL8509684 | 0.89 | CDC7 (0.44) | MAPTNPSR1RECQLTDP1L3MBTL1 | |
| SCHEMBL8510423 | 0.89 | HPGD (0.41) | MAPTNPSR1RECQLPOLBHPGD | |
| SCHEMBL249815 | 0.89 | HPGD (0.41) | MAPTNPSR1RECQLPOLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588478-A1 | AZAINDOLE DERIVATIVE | SBI Biotech Co., Ltd. (JP) | 2013-05-08 | — | — | EP | claimed |
| US-20120135989-A1 | AZAINDOLE DERIVATIVE | CRYSTALGENOMICS, INC. (KR) | 2012-05-31 | — | — | US | claimed |
| WO-2012002568-A1 | AZAINDOLE DERIVATIVE | SBI BIOTECH CO., LTD. (JP) | 2012-01-05 | — | — | WO | claimed |
| US-20120135989-A1 | AZAINDOLE DERIVATIVE | CRYSTALGENOMICS, INC. (KR) | 2012-05-31 | — | — | US | disclosed |
| US-20120135989-A1 | AZAINDOLE DERIVATIVE | CRYSTALGENOMICS, INC. (KR) | 2012-05-31 | — | — | US | disclosed |
| US-20120135989-A1 | AZAINDOLE DERIVATIVE | CRYSTALGENOMICS, INC. (KR) | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120135989-A1 | AZAINDOLE DERIVATIVE | CDC7, CDCA2, CDC5L | MAPT 4131/4885NPSR1 3921/4885RECQL 1629/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.