Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 3/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25275327 | 1.00 | MAPT (0.40) | MAPTKDM4CNPC1PKMRAB9A | |
| SCHEMBL30449368 | 0.90 | ABCB1 (0.44) | MAPTKDM4CNPC1PKMRAB9A | |
| SCHEMBL25271223 | 0.90 | ABCB1 (0.44) | MAPTKDM4CNPC1PKMRAB9A | |
| SCHEMBL25230898 | 0.90 | ABCB1 (0.44) | MAPTKDM4CNPC1PKMRAB9A | |
| SCHEMBL25271086 | 0.80 | ABCB1 (0.36) | CYP1A2CYP3A4CYP2C19ALDH1A1TSHR | |
| SCHEMBL25271087 | 0.80 | ABCB1 (0.36) | CYP1A2CYP3A4CYP2C19ALDH1A1TSHR | |
| SCHEMBL22581153 | 0.80 | CYP1A2 (0.46) | MAPTKDM4CNPC1PKMRAB9A | |
| SCHEMBL30449258 | 0.77 | ABCB1 (0.37) | CYP1A2CYP3A4CYP2C19ALDH1A1TSHR | |
| SCHEMBL24651144 | 0.76 | NPC1 (0.43) | MAPTNPC1PKMRAB9ATP53 | |
| SCHEMBL25230106 | 0.75 | KMT2A (0.42) | MAPTKDM4CALDH1A1TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023110970-A1 | MACROCYCLIC BTK INHIBITORS | NETHERLANDS TRANSLATIONAL RESEARCH CENTER HOLDING B.V (NL) | 2023-06-22 | — | — | WO | disclosed |
| WO-2023110936-A1 | REVERSIBLE MACROCYCLIC KINASE INHIBITORS | NETHERLANDS TRANSLATIONAL RESEARCH CENTER HOLDING B.V (NL) | 2023-06-22 | — | — | WO | disclosed |