Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Docusate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.90 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | MMP14 | P50281 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Docusate SCHEMBL9303137 | 0.99 | RECQL (0.87) | RECQLCYP3A4TSHRTDP1ATM | |
| Docusate SCHEMBL29959 | 0.96 | RECQL (0.97) | RECQLCYP3A4TSHRTDP1ATM | |
| Docusate SCHEMBL23883099 | 0.96 | RECQL (0.97) | RECQLCYP3A4TSHRTDP1ATM | |
| Docusate SCHEMBL157076 | 0.96 | RECQL (0.97) | RECQLCYP3A4TSHRTDP1ATM | |
| Docusate SCHEMBL1996246 | 0.96 | RECQL (0.97) | RECQLCYP3A4TSHRTDP1ATM | |
| Docusate SCHEMBL61651 | 0.95 | RECQL (0.94) | RECQLCYP3A4TSHRTDP1ATM | |
| Docusate SCHEMBL8644531 | 0.95 | RECQL (0.94) | RECQLCYP3A4TSHRTDP1ATM | |
| Docusate SCHEMBL8613686 | 0.95 | RECQL (0.94) | RECQLCYP3A4TSHRTDP1ATM | |
| Docusate SCHEMBL2495512 | 0.95 | RECQL (0.94) | RECQLCYP3A4TSHRTDP1ATM | |
| Docusate SCHEMBL1608235 | 0.95 | RECQL (0.94) | RECQLCYP3A4TSHRTDP1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109133330-B | Preparation method of polypropylene-based supported nano photocatalytic type biological filler | 廊坊市松铭伟业科技有限公司 | 2022-02-08 | — | — | CN | claimed |
| CN-110330712-B | Stable and biodegradable medical film material | 珠海稻田医疗科技有限公司 | 2021-11-23 | — | — | CN | claimed |
| CN-109179632-B | Preparation method of polypropylene-based suspended biological filler for slightly polluted water | 江苏新亿源环保科技有限公司 | 2021-10-26 | — | — | CN | claimed |
| CN-112625780-B | Low-temperature-resistant shield tail sealing grease and preparation method thereof | 中铁建华南建设(广州)高科技产业有限公司 | 2021-08-31 | — | — | CN | claimed |
| CN-110144650-B | Multifunctional pearl polylactic acid blended yarn and preparation method thereof | 立肯诺(上海)新材料科技有限公司 | 2021-03-12 | — | — | CN | claimed |
| CN-112143036-A | Preparation method of nano zinc hydroxystannate/clay composite smoke suppressant | 蚌埠壹石通聚合物复合材料有限公司 | 2020-12-29 | — | — | CN | claimed |
| CN-111941976-A | Edge banding strip and preparation method and application thereof | 东莞欧德雅装饰材料有限公司 | 2020-11-17 | — | — | CN | claimed |
| CN-110760141-A | High cold-resistant PVC film for vehicle | 江苏大海塑料股份有限公司 | 2020-02-07 | — | — | CN | claimed |
| US-20120135057-A1 | ANTIPERSPIRANT COMPOSITIONS AND PRODUCTS HAVING A DISPERSED COOLING SENSATION AGENT AND METHODS FOR MAKING THE SAME | THE DIAL CORPORATION (US) | 2012-05-31 | — | — | US | claimed |
| JP-1167352-A | — | — | None | — | — | JP | disclosed |
| US-11633948-B2 | Method for making lithographic printing plates | EASTMAN KODAK COMPANY (US) | 2023-04-25 | — | — | US | disclosed |
| CN-111690195-B | Nano microporous membrane, and preparation method and application thereof | 江苏厚生新能源科技有限公司 | 2022-12-02 | — | — | CN | disclosed |
| CN-112552621-B | Wear-resistant and impact-resistant cable material and preparation method thereof | 宜宾海丰和锐有限公司 | 2022-09-16 | — | — | CN | disclosed |
| CN-111941976-B | Edge banding strip and preparation method and application thereof | 东莞欧德雅装饰材料有限公司 | 2022-07-22 | — | — | CN | disclosed |
| US-4599296-A | DYE-RELEASING REDOX COMPOUND | FUJI PHOTO FILM CO., LTD. (JP) | 1986-07-08 | — | — | US | disclosed |
| EP-0182617-A2 | Silver halide color photo-sensitive material | KONICA CORPORATION (JP) | 1986-05-28 | — | — | EP | disclosed |
| US-4587206-A | PHOTOTHERMOGRAPHY USING SILVER HALIDE EMULSIONS, DYE-RELEASING REDOX COMPOUND AND HYDROXY-CONTAINING ESTERS FOR STORAGE STABILITY | FUJI PHOTO FILM CO., LTD. (JP) | 1986-05-06 | — | — | US | disclosed |
| US-4536467-A | Heat development of silver halide element with redox dye releaser and stabilizer | FUJI PHOTO FILM CO., LTD. (JP) | 1985-08-20 | — | — | US | disclosed |
| EP-0114675-A2 | Color photographic silver halide light-sensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 1984-08-01 | — | — | EP | disclosed |
| US-4383027-A | 1-PHENYL-3-ANILINO-4-PHENYLTHIO-5-PYRAZOLONE, 1-PHENYL-3-PYRAZOLIDONE | FUJI PHOTO FILM CO., LTD. (JP) | 1983-05-10 | — | — | US | disclosed |