Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 19/20 | 0.39 |
| ▸ | CCRL2 | O00421 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31512219 | 0.99 | BTK (0.39) | BTKCCRL2 | |
| SCHEMBL30497630 | 0.92 | BTK (0.43) | BTK | |
| SCHEMBL25270482 | 0.92 | BTK (0.43) | BTK | |
| SCHEMBL25649350 | 0.89 | BTK (0.43) | BTK | |
| SCHEMBL31125766 | 0.89 | BTK (0.41) | BTK | |
| SCHEMBL25649351 | 0.89 | BTK (0.39) | BTKCCRL2 | |
| SCHEMBL30449214 | 0.83 | BTK (0.45) | BTK | |
| SCHEMBL25225388 | 0.83 | BTK (0.45) | BTK | |
| SCHEMBL25226050 | 0.83 | BTK (0.39) | BTK | |
| SCHEMBL30449777 | 0.83 | BTK (0.39) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4448521-A1 | REVERSIBLE MACROCYCLIC KINASE INHIBITORS | Crossfire Oncology Holding B.V. (NL) | 2024-10-23 | — | — | EP | disclosed |
| WO-2023110936-A1 | REVERSIBLE MACROCYCLIC KINASE INHIBITORS | NETHERLANDS TRANSLATIONAL RESEARCH CENTER HOLDING B.V (NL) | 2023-06-22 | — | — | WO | disclosed |
| WO-2023110936-A1 | REVERSIBLE MACROCYCLIC KINASE INHIBITORS | NETHERLANDS TRANSLATIONAL RESEARCH CENTER HOLDING B.V (NL) | 2023-06-22 | — | — | WO | disclosed |