Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 7/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CASR | P41180 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2531611 | 0.91 | KDM4E (0.39) | AURKARPS6KB1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL2527380 | 0.90 | KMT2A (0.37) | AURKARPS6KB1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL2528486 | 0.90 | ESR1 (0.39) | AURKARPS6KB1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL2527399 | 0.90 | SLC6A2 (0.41) | AURKARPS6KB1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL2528696 | 0.90 | SMN1; SMN2 (0.37) | AURKARPS6KB1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL2528934 | 0.90 | ESR1 (0.39) | AURKARPS6KB1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL2532604 | 0.89 | CYP11B1 (0.36) | AURKARPS6KB1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL2526892 | 0.87 | MAPT (0.38) | AURKARPS6KB1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL2530502 | 0.87 | AURKA (0.32) | AURKARPS6KB1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL2531963 | 0.87 | AURKA (0.44) | AURKARPS6KB1ALDH1A1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8039501-B2 | Synephrine derivatives useful as anti-inflammatory agents | UNIVERSITEIT GENT (BE) | 2011-10-18 | — | — | US | disclosed |
| US-20090029999-A1 | Synephrine derivatives useful as anti-inflammatory agents | UNIVERSITEIT GENT (BE) | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090029999-A1 | Synephrine derivatives useful as anti-inflammatory agents | HRH1, HRH3, HRH2 | AURKA 2197/4885RPS6KB1 1424/4885SLC6A4 3465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.