Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 5/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 2/20 | 0.33 |
| ▸ | CES1 | P23141 | 2/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2527542 | 0.92 | KMT2A (0.46) | KMT2AALDH1A1POLBMAPTHPGD | |
| SCHEMBL2529323 | 0.92 | AOC3 (0.34) | KMT2AALDH1A1AURKARPS6KB1POLB | |
| SCHEMBL2531062 | 0.89 | AURKA (0.38) | KMT2AAURKARPS6KB1MAPTRIPK1 | |
| SCHEMBL2532601 | 0.87 | AURKA (0.33) | AURKARPS6KB1POLBMAPTBACE1 | |
| SCHEMBL2533379 | 0.85 | AOC3 (0.34) | KMT2AAURKARPS6KB1RIPK1MEN1 | |
| SCHEMBL2526900 | 0.84 | AOC3 (0.36) | KMT2AAURKARPS6KB1GPR88AOC3 | |
| SCHEMBL2525569 | 0.84 | BACE1 (0.47) | KMT2AALDH1A1AURKARPS6KB1POLB | |
| SCHEMBL2526962 | 0.84 | HIF1A (0.40) | ALDH1A1AURKARPS6KB1POLBMAPT | |
| SCHEMBL2531040 | 0.83 | AOC3 (0.34) | AURKARPS6KB1GPR88AOC3BCHE | |
| SCHEMBL2526443 | 0.83 | HPGD (0.38) | KMT2AALDH1A1MAPTHPGDXBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8039501-B2 | Synephrine derivatives useful as anti-inflammatory agents | UNIVERSITEIT GENT (BE) | 2011-10-18 | — | — | US | disclosed |
| US-20090029999-A1 | Synephrine derivatives useful as anti-inflammatory agents | UNIVERSITEIT GENT (BE) | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090029999-A1 | Synephrine derivatives useful as anti-inflammatory agents | HRH1, HRH3, HRH2 | KMT2A 2317/4885ALDH1A1 3248/4885AURKA 2197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.