Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 18/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 4/20 | 0.44 |
| ▸ | JAK1 | P23458 | 4/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25243614 | 0.89 | TYK2 (0.52) | TYK2POLBGAATNNI3K | |
| SCHEMBL25242188 | 0.83 | TYK2 (0.45) | TYK2POLBGAAJAK1TNNI3K | |
| SCHEMBL25242499 | 0.82 | TYK2 (0.47) | TYK2POLBGAA | |
| SCHEMBL31300246 | 0.82 | TYK2 (0.53) | TYK2POLBGAAJAK2JAK1 | |
| SCHEMBL25242779 | 0.82 | POLB (0.48) | TYK2POLBGAATNNI3K | |
| SCHEMBL25243670 | 0.82 | POLB (0.48) | TYK2POLBGAATNNI3K | |
| SCHEMBL25243819 | 0.82 | TYK2 (0.66) | TYK2POLBGAATNNI3K | |
| SCHEMBL31247722 | 0.80 | TYK2 (0.63) | TYK2JAK2JAK1KCNH2KIT | |
| SCHEMBL25241440 | 0.80 | TYK2 (0.57) | TYK2POLBGAATNNI3K | |
| SCHEMBL31247606 | 0.78 | TYK2 (0.50) | TYK2POLBGAAJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | claimed |
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | disclosed |