Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 16/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCND3 | P30281 | 1/20 | 0.33 |
| ▸ | CDK7 | P50613 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | CCNH | P51946 | 1/20 | 0.33 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL247517 | 0.88 | PIK3CD (0.40) | PIK3CDPIK3CA | |
| SCHEMBL245631 | 0.88 | PIK3CD (0.40) | PIK3CDPIK3CA | |
| SCHEMBL247385 | 0.86 | PIK3CD (0.38) | PIK3CDPIK3CA | |
| SCHEMBL247584 | 0.86 | PIK3CD (0.38) | PIK3CDPIK3CA | |
| SCHEMBL246190 | 0.85 | ATR (0.38) | PIK3CDPIK3CACCNT1CCNA2CDK2 | |
| SCHEMBL247892 | 0.85 | ATR (0.38) | PIK3CDPIK3CACCNT1CCNA2CDK2 | |
| SCHEMBL14839991 | 0.83 | PIK3CD (0.41) | PIK3CDPIK3CACCNT1CCNA2CDK2 | |
| SCHEMBL248451 | 0.83 | PIK3CA (0.51) | PIK3CDPIK3CA | |
| SCHEMBL248910 | 0.83 | PIK3CA (0.51) | PIK3CDPIK3CA | |
| SCHEMBL247889 | 0.82 | PIK3CA (0.49) | PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588471-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003283-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |