⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3636695 | 0.72 | TDP1 (0.52) | — | |
| SCHEMBL14721746 | 0.71 | EPHX1 (0.44) | — | |
| SCHEMBL1695048 | 0.71 | CYP2D6 (0.40) | — | |
| SCHEMBL21542173 | 0.71 | CYP2D6 (0.53) | — | |
| SCHEMBL20520880 | 0.71 | CYP2D6 (0.37) | — | |
| SCHEMBL24636837 | 0.71 | FUCA1 (0.35) | — | |
| SCHEMBL4396572 | 0.70 | CYP2D6 (0.63) | — | |
| SCHEMBL217411 | 0.70 | — | — | |
| SCHEMBL4396576 | 0.70 | CYP2D6 (0.63) | — | |
| SCHEMBL8644956 | 0.70 | CYP2D6 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11897851-B2 | Heterocyclic GLP-1 agonists | GASHERBRUM BIO, INC. (US) | 2024-02-13 | — | — | US | disclosed |
| WO-2024026338-A1 | N-HETEROCYLIC GPCR RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME, AND METHODS FOR THEIR USE | CARMOT THERAPEUTICS, INC. (US) | 2024-02-01 | — | — | WO | disclosed |
| US-20230192633-A1 | HETEROCYCLIC GLP-1 AGONISTS | GASHERBRUM BIO, INC. | 2023-06-22 | — | — | US | disclosed |