Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 2/20 | 0.37 |
| ▸ | TEAD4 | Q15561 | 2/20 | 0.37 |
| ▸ | TEAD2 | Q15562 | 2/20 | 0.37 |
| ▸ | TEAD3 | Q99594 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | PRKCB | P05771 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | LYN | P07948 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25243401 | 0.86 | TEAD1 (0.42) | TEAD1TEAD4TEAD2TEAD3NAMPT | |
| SCHEMBL30424238 | 0.86 | TEAD1 (0.42) | TEAD1TEAD4TEAD2TEAD3NAMPT | |
| SCHEMBL25600315 | 0.86 | TEAD1 (0.52) | TEAD1TEAD4TEAD2TEAD3NAMPT | |
| SCHEMBL25241249 | 0.85 | RARG (0.39) | TEAD1TEAD4TEAD2TEAD3AKT1 | |
| SCHEMBL25751810 | 0.84 | TEAD1 (0.55) | TEAD1TEAD4TEAD2TEAD3NAMPT | |
| SCHEMBL25751802 | 0.83 | TEAD1 (0.43) | TEAD1TEAD4TEAD2TEAD3NAMPT | |
| SCHEMBL25751808 | 0.81 | TEAD1 (0.41) | TEAD1TEAD4TEAD2TEAD3NAMPT | |
| SCHEMBL25205886 | 0.81 | TEAD1 (0.36) | TEAD1TEAD4TEAD2TEAD3RARG | |
| SCHEMBL30424235 | 0.81 | TEAD1 (0.36) | TEAD1TEAD4TEAD2TEAD3RARG | |
| SCHEMBL25751804 | 0.81 | TEAD1 (0.41) | TEAD1TEAD4TEAD2TEAD3NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230202984-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2023-06-29 | — | — | US | disclosed |
| US-20230202984-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2023-06-29 | — | — | US | disclosed |
| US-20230202984-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2023-06-29 | — | — | US | disclosed |
| WO-2023097195-A1 | THERAPEUTIC INDAZOLE COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2023-06-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230202984-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE | VHL, TP53, MCL1 | TEAD1 282/4885TEAD4 162/4885TEAD2 129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.