Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bromocriptine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 known ✓ | P35462 | 5/20 | 1.00 |
| ▸ | DRD2 known ✓ | P14416 | 4/20 | 1.00 |
| ▸ | DRD4 known ✓ | P21917 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 1.00 |
| ▸ | MAPT | P10636 | 10/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 9/20 | 1.00 |
| ▸ | MEN1 | O00255 | 8/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 8/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 7/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 7/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 5/20 | 1.00 |
| ▸ | DRD1 | P21728 | 5/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 4/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 4/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 4/20 | 1.00 |
| ▸ | ADRA1D | P25100 | 4/20 | 1.00 |
| ▸ | HTR2A | P28223 | 4/20 | 1.00 |
| ▸ | HTR2C | P28335 | 4/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromocriptine SCHEMBL186901 | 1.00 | KDM4E (1.00) | KDM4EMAPTCYP3A4MEN1KMT2A | |
| Bromocriptine SCHEMBL29414631 | 1.00 | KDM4E (1.00) | KDM4EMAPTCYP3A4MEN1KMT2A | |
| Bromocriptine SCHEMBL29364057 | 1.00 | KDM4E (1.00) | KDM4EMAPTCYP3A4MEN1KMT2A | |
| Bromocriptine SCHEMBL8032620 | 1.00 | KDM4E (1.00) | KDM4EMAPTCYP3A4MEN1KMT2A | |
| Bromocriptine SCHEMBL19276395 | 1.00 | KDM4E (1.00) | KDM4EMAPTCYP3A4MEN1KMT2A | |
| Bromocriptine SCHEMBL9526627 | 1.00 | KDM4E (1.00) | KDM4EMAPTCYP3A4MEN1KMT2A | |
| Bromocriptine SCHEMBL23468147 | 1.00 | KDM4E (1.00) | KDM4EMAPTCYP3A4MEN1KMT2A | |
| Bromocriptine SCHEMBL3134319 | 1.00 | KDM4E (1.00) | KDM4EMAPTCYP3A4MEN1KMT2A | |
| Bromocriptine SCHEMBL3134317 | 1.00 | KDM4E (1.00) | KDM4EMAPTCYP3A4MEN1KMT2A | |
| Bromocriptine SCHEMBL11890530 | 1.00 | KDM4E (1.00) | KDM4EMAPTCYP3A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 47458 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| CN-122075697-A | SFMBT2 gene and application of bromocriptine in repairing damaged cartilage and preventing and treating osteoarthritis | — | 2026-05-26 | — | — | CN | claimed |
| WO-2026106939-A1 | IMPROVING SYMPTOMS IN MID- TO LATE-STAGE PARKINSON'S DISEASE PATIENTS USING WITH DEEP BRAIN STIMULATION | VANDERBILT UNIVERSITY (US) | 2026-05-21 | — | — | WO | claimed |
| US-20260131140-A1 | MODIFYING EARLY-STAGE PARKINSON'S DISEASE PROGRESSION WITH DEEP BRAIN STIMULATION | VANDERBILT UNIV (US) | 2026-05-14 | — | — | US | claimed |
| US-12616693-B2 | Bromocriptine formulations | VEROSCIENCE LLC (US) | 2026-05-05 | — | — | US | claimed |
| US-20260108619-A1 | CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2026-04-23 | — | — | US | claimed |
| US-12594388-B2 | Device to deliver a predetermined amount of a substance to a natural orifice of the body | APTARGROUP, INC. (US) | 2026-04-07 | — | — | US | claimed |
| US-20260092141-A1 | SERIES OF POLYMERS HAVING PROPERTIES OF ACID-SENSITIVE DEGRADATION AND TEMPERATURE SENSITIVITY AND DRUG LOADING COMPOSITION THEREOF | NANJING FANTAI CHEMICAL PHARMACEUTICAL RESEARCH INSTITUTE (CN) | 2026-04-02 | — | — | US | claimed |
| EP-4717276-A2 | OPHTHALMIC COMPOSITIONS COMPRISING LEVODOPA, AN ANTIOXIDANT AND AN AQUEOUS CARRIER | University of Canberra (AU) | 2026-04-01 | — | — | EP | claimed |
| EP-4712959-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING 2,3,4,5-TETRAHYDRO-BENZOTHIEPIN-1,1-DIOXIDE DERIVATIVES AND THE USE THEREOF | Mirum Pharmaceuticals, Inc. (US) | 2026-03-25 | — | — | EP | claimed |
| EP-0041030-B1 | COMPOSITIONS FOR TOPICAL USE CONTAINING ERGOT OR VINCA ROSEA ALKALOIDS FOR TREATMENT OF HYPERSEBORRHOEA, AND THEIR PREPARATION | PIERRE FABRE S.A. (FR) | 1984-03-14 | — | — | EP | claimed |
| US-4411882-A | AN ERGOT ALKALOID AND A POLYALKOXYALKYLENE STEROL ETHER | SANDOZ LTD. (CH) | 1983-10-25 | — | — | US | claimed |
| US-4384975-A | SOLVENT REMOVAL FROM AN OIL IN WATER EMULSION CONTAINING SODIUM OLEATE OR POTASSIUM OLEATE | SANDOZ, INC. (US) | 1983-05-24 | — | — | US | claimed |
| US-4382921-A | Method for treatment of psoriasis | SERONO PHARMACEUTICAL PARTNERS A MA LIMITED PARTNERSHIP | 1983-05-10 | — | — | US | claimed |
| US-4366145-A | Soft gelatin capsule with a liquid ergot alkaloid center fill solution and method of preparation | SANDOZ, INC. (US) | 1982-12-28 | — | — | US | claimed |
| EP-0041030-A1 | Compositions for topical use containing Ergot or Vinca Rosea alkaloids for treatment of hyperseborrhoea, and their preparation | PIERRE FABRE S.A. (FR) | 1981-12-02 | — | — | EP | claimed |
| EP-0036145-A1 | An orally administered drug form comprising a polar bioactive agent and an adjuvant | INTERx RESEARCH CORPORATION (US) | 1981-09-23 | — | — | EP | claimed |
| US-4225605-A | Ergolene or ergoline compounds for treating congestive heart failure | SANDOZ LTD. (CH) | 1980-09-30 | — | — | US | claimed |
| US-4202897-A | IMIDAZON2,1-AE ISOINDOLES AND ISOQUINOLINES | SANDOZ, INC. (US) | 1980-05-13 | — | — | US | claimed |
| US-4166800-A | Processes for preparation of microspheres | SANDOZ, INC. (US) | 1979-09-04 | — | — | US | claimed |