Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2775755 | 0.99 | KCNH2 (0.43) | KCNH2ENPP2TRPV1SRCS1PR5 | |
| SCHEMBL2775752 | 0.99 | KCNH2 (0.43) | KCNH2ENPP2TRPV1SRCS1PR5 | |
| SCHEMBL2777056 | 0.99 | KCNH2 (0.43) | KCNH2ENPP2TRPV1SRCS1PR5 | |
| SCHEMBL2452603 | 0.99 | KCNH2 (0.43) | KCNH2ENPP2TRPV1SRCS1PR5 | |
| SCHEMBL2777408 | 0.91 | KCNH2 (0.41) | KCNH2ENPP2TRPV1SRCS1PR5 | |
| SCHEMBL2777405 | 0.91 | KCNH2 (0.41) | KCNH2ENPP2TRPV1SRCS1PR5 | |
| SCHEMBL2451591 | 0.89 | KCNH2 (0.41) | KCNH2TRPV1SRCABL1HRH3 | |
| SCHEMBL2452030 | 0.89 | KCNH2 (0.41) | KCNH2ENPP2SRCABL1HRH3 | |
| SCHEMBL2452283 | 0.89 | KCNH2 (0.41) | KCNH2ENPP2SRCABL1HRH3 | |
| SCHEMBL2451587 | 0.89 | KCNH2 (0.41) | KCNH2TRPV1SRCABL1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364088-A1 | BICYCLIC ARYL SPHINGOSINE 1-PHOSPHATE ANALOGS | Biogen Idec MA Inc. (US) | 2011-09-14 | — | — | EP | disclosed |
| WO-2010051030-A1 | BICYCLIC ARYL SPHINGOSINE 1-PHOSPHATE ANALOGS | BIOGEN IDEC MA INC. (US) | 2010-05-06 | — | — | WO | disclosed |