Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.38 |
| ▸ | JMJD6 | Q6NYC1 | 3/20 | 0.37 |
| ▸ | APLNR | P35414 | 6/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 2/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25259860 | 0.90 | BTK (0.44) | BRD4CREBBPJMJD6BTK | |
| SCHEMBL25376670 | 0.90 | BTK (0.44) | BRD4CREBBPJMJD6BTK | |
| SCHEMBL25263611 | 0.88 | IDH1 (0.39) | JMJD6 | |
| SCHEMBL26193402 | 0.84 | JMJD6 (0.36) | BRD4CREBBPJMJD6 | |
| SCHEMBL30561751 | 0.84 | BTK (0.45) | BRD4CREBBPJMJD6BTK | |
| SCHEMBL25377645 | 0.84 | BTK (0.45) | BRD4CREBBPJMJD6BTK | |
| SCHEMBL25377637 | 0.84 | BTK (0.45) | BRD4CREBBPJMJD6BTK | |
| SCHEMBL25258171 | 0.81 | JMJD6 (0.43) | JMJD6APLNRHCRTR1HCRTR2KDM5A | |
| SCHEMBL25826079 | 0.81 | BRD4 (0.33) | BRD4CREBBPDYRK1A | |
| SCHEMBL25294718 | 0.81 | JMJD6 (0.38) | JMJD6APLNRHCRTR1HCRTR2KDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023122780-A9 | 2-PYRAZOLE ANILINES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD | THE KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2023-11-30 | — | — | WO | disclosed |
| WO-2023122780-A2 | 2-PYRAZOLE ANILINES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD | THE KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2023-06-29 | — | — | WO | disclosed |