Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NMT2 | O60551 | 1/20 | 0.34 |
| ▸ | NMT1 | P30419 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | SLC26A4 | O43511 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | BTK | Q06187 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30758019 | 1.00 | CHEK1 (0.36) | CHEK1KDM4EALDH1A1LMNAHTT | |
| SCHEMBL25261247 | 1.00 | CHEK1 (0.36) | CHEK1KDM4EALDH1A1LMNAHTT | |
| SCHEMBL25296170 | 0.90 | GAA (0.42) | CHEK1KDM4EALDH1A1LMNAHTT | |
| SCHEMBL25296169 | 0.90 | GAA (0.42) | CHEK1KDM4EALDH1A1LMNAHTT | |
| Hydrochloric Acid SCHEMBL29630291 | 0.90 | GAA (0.41) | CHEK1KDM4EALDH1A1LMNAHTT | |
| Hydrochloric Acid SCHEMBL29095870 | 0.90 | GAA (0.41) | CHEK1KDM4EALDH1A1LMNAHTT | |
| SCHEMBL25294619 | 0.88 | CHEK1 (0.37) | CHEK1KDM4EALDH1A1LMNAHTT | |
| SCHEMBL25294620 | 0.88 | CHEK1 (0.37) | CHEK1KDM4EALDH1A1LMNAHTT | |
| SCHEMBL24484438 | 0.87 | KDM4E (0.35) | KDM4EALDH1A1LMNAHTTMAPT | |
| SCHEMBL29630070 | 0.87 | KDM4E (0.35) | KDM4EALDH1A1LMNAHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024013052-A1 | NOVEL USE | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.3) LIMITED (GB) | 2024-01-18 | — | — | WO | disclosed |
| US-20230220037-A1 | NOVEL USE | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.3) LIMITED (GB) | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230220037-A1 | NOVEL USE | RAMP3, TRPM7, TRPM4 | CHEK1 1835/4885KDM4E 3081/4885ALDH1A1 3787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.