Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 10/20 | 0.62 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.62 |
| ▸ | JAK2 | O60674 | 2/20 | 0.62 |
| ▸ | JAK1 | P23458 | 2/20 | 0.62 |
| ▸ | TYK2 | P29597 | 2/20 | 0.62 |
| ▸ | STAT6 | P42226 | 8/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.50 |
| ▸ | BTK | Q06187 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2478491 | 0.86 | JAK3 (0.69) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2480672 | 0.84 | JAK3 (0.67) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2474883 | 0.84 | JAK3 (0.72) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2697822 | 0.82 | JAK3 (0.63) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2512761 | 0.82 | JAK3 (0.60) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2696032 | 0.82 | JAK3 (0.72) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2695578 | 0.81 | JAK3 (0.67) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2474482 | 0.80 | JAK3 (0.65) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2692165 | 0.80 | JAK3 (0.64) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2481423 | 0.80 | JAK3 (0.64) | JAK3IRAK4JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2380877-A1 | PYRIDINE-3-CARBOXYAMIDE DERIVATIVE | Kowa Company, Ltd. (JP) | 2011-10-26 | — | — | EP | claimed |
| EP-2380877-A1 | PYRIDINE-3-CARBOXYAMIDE DERIVATIVE | Kowa Company, Ltd. (JP) | 2011-10-26 | — | — | EP | disclosed |