SCHEMBL25314720

SCHEMBL25314720

FC(F)(F)c1cccc(C2(NC[C@@H]3CCCN3)CCC2)c1

nearest known ligand 0.51

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 3/20 0.42
SLC6A3 Q01959 2/20 0.42
DRD2 P14416 1/20 0.41
DRD3 P35462 1/20 0.41
IDO1 P14902 1/20 0.40
TDO2 P48775 1/20 0.40
KCNN4 O15554 2/20 0.40
OPRM1 P35372 1/20 0.39
OPRK1 P41145 1/20 0.39
OPRL1 P41146 1/20 0.39
SLC6A2 P23975 1/20 0.39
KDM1A O60341 2/20 0.39
HTR6 P50406 1/20 0.39
SCN9A Q15858 2/20 0.38
IL1B P01584 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25312630 1.00 SLC6A4 (0.42) SLC6A4SLC6A3DRD2DRD3IDO1
SCHEMBL29492574 0.84 IDO1 (0.43) IDO1TDO2KCNN4SCN9AIL1B
SCHEMBL25311867 0.84 IDO1 (0.43) IDO1TDO2KCNN4SCN9AIL1B
SCHEMBL25313136 0.83 TACR1 (0.41) SLC6A3KCNN4SCN9A
SCHEMBL25314944 0.83 TACR1 (0.41) SLC6A3KCNN4SCN9A
SCHEMBL25311806 0.81 KCNN4 (0.50) IDO1TDO2KCNN4OPRK1SLC6A2
SCHEMBL25311480 0.81 KCNN4 (0.50) IDO1TDO2KCNN4OPRK1SLC6A2
SCHEMBL25312157 0.74 HCRTR2 (0.36) KCNN4OPRL1KDM1A
SCHEMBL25310800 0.74 HCRTR2 (0.36) KCNN4OPRL1KDM1A
SCHEMBL29492580 0.74 HCRTR2 (0.36) KCNN4OPRL1KDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240034717-A1 NOVEL POTASSIUM CHANNEL INHIBITORS SANIONA A/S (DK) 2024-02-01 US claimed
EP-4217065-A1 NOVEL POTASSIUM CHANNEL INHIBITORS Saniona A/S (DK) 2023-08-02 EP claimed
CN-116368112-A Novel potassium channel inhibitors 萨尼奥纳有限责任公司 2023-06-30 CN claimed
WO-2022063767-A1 NOVEL POTASSIUM CHANNEL INHIBITORS SANIONA A/S (DK) 2022-03-31 WO claimed
US-20240034717-A1 NOVEL POTASSIUM CHANNEL INHIBITORS SANIONA A/S (DK) 2024-02-01 US disclosed
EP-4217065-A1 NOVEL POTASSIUM CHANNEL INHIBITORS Saniona A/S (DK) 2023-08-02 EP disclosed
CN-116368112-A Novel potassium channel inhibitors 萨尼奥纳有限责任公司 2023-06-30 CN disclosed
WO-2022063767-A1 NOVEL POTASSIUM CHANNEL INHIBITORS SANIONA A/S (DK) 2022-03-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240034717-A1 NOVEL POTASSIUM CHANNEL INHIBITORS KCNN2, KCNJ2, KCNN1 SLC6A4 623/4885SLC6A3 539/4885DRD2 3915/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.