Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 0.53 |
| ▸ | AKT2 | P31751 | 20/20 | 0.53 |
| ▸ | AKT3 | Q9Y243 | 20/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2531668 | 0.79 | AKT1 (0.57) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL2517428 | 0.75 | AKT1 (0.56) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL2517433 | 0.75 | AKT1 (0.56) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL2517506 | 0.75 | AKT1 (0.56) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL17424838 | 0.71 | AKT1 (0.81) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL192276 | 0.71 | AKT1 (0.81) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL191293 | 0.71 | AKT1 (0.81) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL193110 | 0.71 | AKT1 (0.81) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| Hydrochloric Acid SCHEMBL3120703 | 0.71 | AKT1 (0.51) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL191789 | 0.71 | AKT1 (0.85) | AKT1AKT2AKT3PIK3CAPRKG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329709-B2 | 5H-cyclopenta[D]pyrimidines as AKT protein kinase inhibitors | GENENTECH, INC. (US) | 2012-12-11 | — | — | US | disclosed |
| US-20110251181-A1 | 5H-CYCLOPENTA[D]PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | GENENTECH, INC. (US) | 2011-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251181-A1 | 5H-CYCLOPENTA[D]PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | AKT3, PIK3CA, AKT2 | AKT1 5/4885AKT2 3/4885AKT3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.