⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8404454 | 0.76 | — | — | |
| SCHEMBL27991247 | 0.73 | — | — | |
| SCHEMBL9147903 | 0.73 | — | — | |
| SCHEMBL1645331 | 0.70 | — | — | |
| SCHEMBL11158635 | 0.68 | — | — | |
| SCHEMBL9696096 | 0.66 | BTK (0.40) | — | |
| SCHEMBL19242505 | 0.65 | PARP1 (0.41) | — | |
| SCHEMBL65108 | 0.64 | — | — | |
| SCHEMBL15215750 | 0.62 | KMT2A (0.52) | — | |
| Iodide SCHEMBL27655122 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102675217-A | Preparation method of 5-bromine-2-methyl-4(1H)-pyrimidone | CGENE TECH SUZHOU CHINA CO LTD | 2012-09-19 | — | — | CN | claimed |
| CN-118434727-A | Substituted pyrimidinone derivatives, pharmaceutical compositions and pharmaceutical uses thereof | 上海海雁医药科技有限公司 | 2024-08-02 | — | — | CN | disclosed |
| WO-2023125812-A1 | SUBSTITUTED PYRIMIDONE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND MEDICAL USE THEREOF | 上海海雁医药科技有限公司 | 2023-07-06 | — | — | WO | disclosed |
| CN-102675217-A | Preparation method of 5-bromine-2-methyl-4(1H)-pyrimidone | CGENE TECH SUZHOU CHINA CO LTD | 2012-09-19 | — | — | CN | disclosed |
| CN-102675217-A | Preparation method of 5-bromine-2-methyl-4(1H)-pyrimidone | CGENE TECH SUZHOU CHINA CO LTD | 2012-09-19 | — | — | CN | disclosed |
| CN-102675217-A | Preparation method of 5-bromine-2-methyl-4(1H)-pyrimidone | CGENE TECH SUZHOU CHINA CO LTD | 2012-09-19 | — | — | CN | disclosed |