Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | POLQ | O75417 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | USP14 | P54578 | 1/20 | 0.30 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30490463 | 1.00 | BACE1 (0.35) | BACE1TACR1POLQGAAUSP14 | |
| SCHEMBL23947172 | 0.85 | MEN1 (0.39) | BACE1GAAMAPT | |
| SCHEMBL31139996 | 0.85 | MEN1 (0.39) | BACE1GAAMAPT | |
| SCHEMBL21722860 | 0.85 | BACE1 (0.35) | BACE1TACR1MAPT | |
| SCHEMBL21722894 | 0.77 | SMARCA2 (0.50) | — | |
| SCHEMBL17979163 | 0.77 | BACE1 (0.32) | BACE1 | |
| SCHEMBL5743751 | 0.76 | BACE1 (0.31) | BACE1 | |
| SCHEMBL29274171 | 0.75 | BACE1 (0.33) | BACE1 | |
| SCHEMBL21722877 | 0.74 | BACE1 (0.30) | BACE1 | |
| SCHEMBL23213525 | 0.73 | CASR (0.36) | BACE1TACR1GAAUSP14MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219488-A1 | METHOD FOR THE PREPARATION OF UREA COMPOUNDS AS SMARCA2/BRM-ATPASE INHIBITORS | Novartis AG (CH) | 2023-08-02 | — | — | EP | disclosed |