Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 9/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.32 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.32 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.31 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.30 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.30 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25321504 | 1.00 | TNF (0.34) | TNFHDAC3HDAC1HDAC6PSMB5 | |
| SCHEMBL25321355 | 0.88 | TIPARP (0.32) | TNFHDAC3HDAC1HDAC6PSMB5 | |
| SCHEMBL30550612 | 0.88 | TIPARP (0.32) | TNFHDAC3HDAC1HDAC6PSMB5 | |
| SCHEMBL25321350 | 0.88 | TIPARP (0.32) | TNFHDAC3HDAC1HDAC6PSMB5 | |
| SCHEMBL25318213 | 0.72 | AAK1 (0.36) | TNFHDAC3HDAC1HDAC6PSMB5 | |
| SCHEMBL25318208 | 0.72 | AAK1 (0.36) | TNFHDAC3HDAC1HDAC6PSMB5 | |
| SCHEMBL25320186 | 0.72 | TNF (0.36) | TNFHDAC3HDAC1HDAC6PSMB5 | |
| SCHEMBL30550660 | 0.71 | TNF (0.38) | TNFHDAC3HDAC1HDAC6PSMB5 | |
| SCHEMBL30550681 | 0.71 | PRMT5 (0.34) | TNFHDAC3HDAC1HDAC6 | |
| SCHEMBL25319011 | 0.71 | TNF (0.37) | TNFHDAC3HDAC1HDAC6PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023147418-A1 | PARP7 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2023-08-03 | — | — | WO | disclosed |