Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 3/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.32 |
| ▸ | SNCA | P37840 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25323670 | 0.94 | SNCA (0.34) | SNCA | |
| SCHEMBL30322970 | 0.94 | SNCA (0.34) | SNCA | |
| SCHEMBL24365153 | 0.87 | NPC1 (0.46) | NPC1RAB9ADRD3DRD2HTR1A | |
| SCHEMBL31145106 | 0.87 | NPC1 (0.46) | NPC1RAB9ADRD3DRD2HTR1A | |
| SCHEMBL25322458 | 0.84 | NPC1 (0.46) | NPC1RAB9ADRD3DRD2HTR1A | |
| SCHEMBL24364822 | 0.80 | SNCA (0.35) | NPC1RAB9ADRD2SMN1; SMN2NPSR1 | |
| SCHEMBL25322583 | 0.80 | NPC1 (0.43) | NPC1RAB9ADRD3DRD2HTR1A | |
| SCHEMBL25319879 | 0.79 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2NPSR1CNR2 | |
| SCHEMBL25320553 | 0.79 | NPC1 (0.44) | NPC1RAB9ADRD3DRD2HTR1A | |
| SCHEMBL24363858 | 0.78 | NPC1 (0.39) | NPC1RAB9ADRD2SMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146990-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |