SCHEMBL25323316

SCHEMBL25323316

CC1CCN(C(=O)C(=O)Nc2cnc(N)c3cnn(COCC[Si](C)(C)C)c23)C(c2ccccc2)C1.CC1CCN(C(=O)C(N)=O)C(c2ccccc2)C1

nearest known ligand 0.45

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PRMT5 O14744 12/20 0.45
WDR77 Q9BQA1 8/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25323311 1.00 PRMT5 (0.45) PRMT5WDR77
SCHEMBL30551224 0.97 PRMT5 (0.46) PRMT5WDR77
SCHEMBL25325133 0.97 PRMT5 (0.46) PRMT5WDR77
SCHEMBL25325130 0.97 PRMT5 (0.46) PRMT5WDR77
SCHEMBL30551156 0.87 PRMT5 (0.53) PRMT5WDR77
SCHEMBL25323179 0.87 PRMT5 (0.53) PRMT5WDR77
SCHEMBL25321568 0.86 PRMT5 (0.45) PRMT5WDR77
SCHEMBL25321705 0.83 PRMT5 (0.46) PRMT5WDR77
SCHEMBL30551060 0.83 PRMT5 (0.46) PRMT5WDR77
SCHEMBL25918200 0.83 PRMT5 (0.46) PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023146990-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS, INC. (US) 2023-08-03 WO disclosed