Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIPARP | Q7Z3E1 | 20/20 | 0.83 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25323845 | 1.00 | TIPARP (0.83) | TIPARPTNKSPARP14PARP10PARP12 | |
| SCHEMBL30550796 | 0.94 | TIPARP (0.80) | TIPARPTNKSPARP14PARP10PARP12 | |
| SCHEMBL25317204 | 0.94 | TIPARP (0.80) | TIPARPTNKSPARP14PARP10PARP12 | |
| SCHEMBL25317202 | 0.94 | TIPARP (0.80) | TIPARPTNKSPARP14PARP10PARP12 | |
| SCHEMBL30550712 | 0.93 | TIPARP (0.79) | TIPARPTNKSPARP14PARP10PARP12 | |
| SCHEMBL25321880 | 0.93 | TIPARP (0.79) | TIPARPTNKSPARP14PARP10PARP12 | |
| SCHEMBL25321882 | 0.93 | TIPARP (0.79) | TIPARPTNKSPARP14PARP10PARP12 | |
| SCHEMBL25902967 | 0.93 | TIPARP (0.83) | TIPARPTNKSPARP14PARP10PARP12 | |
| SCHEMBL26658791 | 0.93 | TIPARP (0.83) | TIPARPTNKSPARP14PARP10PARP12 | |
| SCHEMBL25901206 | 0.92 | TIPARP (0.72) | TIPARPTNKSPARP14PARP10PARP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250066328-A1 | PARP7 INHIBITORS | GILEAD SCIENCES, INC. | 2025-02-27 | — | — | US | claimed |
| US-12459922-B2 | PARP7 inhibitors | GILEAD SCIENCES, INC. (US) | 2025-11-04 | — | — | US | disclosed |
| US-20250066328-A1 | PARP7 INHIBITORS | GILEAD SCIENCES, INC. | 2025-02-27 | — | — | US | disclosed |
| US-20230365529-A1 | PARP7 INHIBITORS | GILEAD SCIENCES, INC. | 2023-11-16 | — | — | US | disclosed |
| WO-2023147418-A1 | PARP7 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2023-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250066328-A1 | PARP7 INHIBITORS | PARP1, PARP2, PARP8 | TIPARP 524/4885TNKS 19/4885PARP14 11/4885 |
| US-12459922-B2 | PARP7 inhibitors | PARP1, PARP11, PARP2 | TIPARP 491/4885TNKS 19/4885PARP14 10/4885 |
| US-20230365529-A1 | PARP7 INHIBITORS | PARP1, PARP11, PARP2 | TIPARP 491/4885TNKS 19/4885PARP14 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.