SCHEMBL25323918

SCHEMBL25323918

Cn1cc(Br)c(-c2ccc(C(F)F)cn2)n1

nearest known ligand 0.34

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CSNK1D P48730 5/20 0.34
MAPK14 Q16539 4/20 0.34
PDE2A O00408 1/20 0.33
HTR2A P28223 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.30
FLT3 P36888 1/20 0.30
SYK P43405 1/20 0.30
AURKB Q96GD4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25323581 0.82 CSNK1D (0.34) CSNK1DMAPK14FLT3SYKAURKB
SCHEMBL25323855 0.80 CSNK1D (0.50) CSNK1DMAPK14HTR2AFLT3SYK
SCHEMBL25324100 0.78 CCR1 (0.48) CSNK1DMAPK14SMN1; SMN2
SCHEMBL25323906 0.78 SMN1; SMN2 (0.41) CSNK1DMAPK14PDE2AHTR2ASMN1; SMN2
SCHEMBL25324559 0.77 HTR2A (0.40) CSNK1DMAPK14HTR2ASMN1; SMN2
SCHEMBL30509482 0.73 CSNK1D (0.42) CSNK1DMAPK14FLT3SYKAURKB
SCHEMBL24240183 0.71 BRD4 (0.38) PDE2A
SCHEMBL30509514 0.71 CSNK1D (0.42) CSNK1DMAPK14FLT3SYKAURKB
SCHEMBL13874006 0.70 KDM4E (0.43) SMN1; SMN2
SCHEMBL25320188 0.70 SMN1; SMN2 (0.32) SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230339900-A1 CASEIN KINASE 1 DELTA MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2023-10-26 US disclosed
US-20230339900-A1 CASEIN KINASE 1 DELTA MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2023-10-26 US disclosed
US-20230339900-A1 CASEIN KINASE 1 DELTA MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2023-10-26 US disclosed
EP-4214199-A1 CASEIN KINASE 1 DELTA MODULATORS JANSSEN Pharmaceutica NV (BE) 2023-07-26 EP disclosed
CN-116490503-A Casein kinase 1 delta modulators 詹森药业有限公司 2023-07-25 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230339900-A1 CASEIN KINASE 1 DELTA MODULATORS CSNK1D, CSNK1A1, CSNK2A1 CSNK1D 1/4885MAPK14 441/4885PDE2A 2594/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.