Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 3/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.40 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.40 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.40 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.40 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25913668 | 0.86 | DYRK1A (0.45) | PPARADYRK1ATRPV1AKR1B1HDAC6 | |
| SCHEMBL30515073 | 0.86 | DYRK1A (0.45) | PPARADYRK1ATRPV1AKR1B1HDAC6 | |
| SCHEMBL25321539 | 0.82 | DYRK1A (0.42) | PPARADYRK1ATRPV1AKR1B1HDAC6 | |
| SCHEMBL20509420 | 0.80 | DYRK1A (0.51) | PPARADYRK1ATRPV1AKR1B1HDAC6 | |
| SCHEMBL25322263 | 0.78 | PPARA (0.47) | PPARADYRK1ATRPV1AKR1B1HDAC6 | |
| SCHEMBL25323599 | 0.75 | PPARA (0.44) | PPARADYRK1ATRPV1AKR1B1HDAC6 | |
| SCHEMBL4006075 | 0.74 | DYRK1A (0.60) | PPARADYRK1ATRPV1AKR1B1HDAC6 | |
| SCHEMBL2945307 | 0.73 | HDAC6 (0.70) | PPARADYRK1ATRPV1AKR1B1HDAC6 | |
| SCHEMBL20509355 | 0.73 | DYRK1A (0.48) | PPARADYRK1ATRPV1AKR1B1HDAC6 | |
| SCHEMBL30466621 | 0.73 | DYRK1A (0.48) | PPARADYRK1ATRPV1AKR1B1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146990-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |
| WO-2023146989-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |