SCHEMBL25325890

C[C@H]1CC[C@H](c2cccc(Cl)c2)N(C(=O)C(=O)OCC(F)(F)F)C1.C[C@H]1CC[C@H](c2cccc(Cl)c2)N(C(=O)C(N)=O)C1

nearest known ligand 0.38

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	PRMT5	O14744	9/20	0.38

▸	WDR77	Q9BQA1	2/20	0.38

▸	TP53	P04637	4/20	0.35

▸	MDM2	Q00987	4/20	0.35

▸	RIPK1	Q13546	1/20	0.35

▸	TACR1	P25103	1/20	0.35

▸	FFAR2	O15552	1/20	0.34

▸	CACNA1B	Q00975	1/20	0.34

▸	ADAM17	P78536	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL25323660	0.95	PRMT5 (0.39)	PRMT5WDR77TP53MDM2RIPK1
SCHEMBL25323662	0.95	PRMT5 (0.39)	PRMT5WDR77TP53MDM2RIPK1
SCHEMBL25322165	0.92	PRMT5 (0.36)	PRMT5WDR77TP53MDM2RIPK1
SCHEMBL30551045	0.92	PRMT5 (0.36)	PRMT5WDR77TP53MDM2RIPK1
SCHEMBL30551629	0.86	PRMT5 (0.40)	PRMT5WDR77
SCHEMBL25322224	0.86	PRMT5 (0.40)	PRMT5WDR77
SCHEMBL30551659	0.86	PRMT5 (0.47)	PRMT5WDR77RIPK1FFAR2
SCHEMBL25923592	0.86	PRMT5 (0.47)	PRMT5WDR77RIPK1FFAR2
SCHEMBL25323600	0.86	PRMT5 (0.47)	PRMT5WDR77RIPK1FFAR2
SCHEMBL25320105	0.85	PRMT5 (0.35)	PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-4469455-A1	COMPOUNDS AND METHODS OF USE	Tango Therapeutics, Inc. (US)	2024-12-04	—	—	EP	disclosed
WO-2023146990-A1	COMPOUNDS AND METHODS OF USE	TANGO THERAPEUTICS, INC. (US)	2023-08-03	—	—	WO	disclosed