SCHEMBL25326154

SCHEMBL25326154

C[C@@H]1CN(C(=O)C(=O)Nc2cncc3cn[nH]c23)[C@@H](c2ccc(F)cc2)CN1C(=O)O

nearest known ligand 0.39

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PRMT5 O14744 20/20 0.39
WDR77 Q9BQA1 6/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25329073 0.92 PRMT5 (0.44) PRMT5WDR77
SCHEMBL30522970 0.89 PRMT5 (0.37) PRMT5WDR77
SCHEMBL25327238 0.89 PRMT5 (0.37) PRMT5WDR77
SCHEMBL25327240 0.89 PRMT5 (0.37) PRMT5WDR77
SCHEMBL25325556 0.84 PRMT5 (0.44) PRMT5WDR77
SCHEMBL25910784 0.82 PRMT5 (0.43) PRMT5WDR77
SCHEMBL25326867 0.82 PRMT5 (0.41) PRMT5WDR77
SCHEMBL25327081 0.81 PRMT5 (0.39) PRMT5WDR77
SCHEMBL25324769 0.80 PRMT5 (0.39) PRMT5WDR77
SCHEMBL25327462 0.79 PRMT5 (0.41) PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023146991-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS, INC. (US) 2023-08-03 WO disclosed