SCHEMBL2532669

SCHEMBL2532669

CS(=O)(=O)Nc1ccc(C(CCc2ccc(C(F)(F)F)cc2Cl)CNC(=O)c2ccccc2O)cc1F

nearest known ligand 0.57

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 20/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2531834 0.91 TRPV1 (0.49) TRPV1
SCHEMBL2531659 0.89 TRPV1 (0.48) TRPV1
SCHEMBL2528188 0.89 TRPV1 (0.47) TRPV1
SCHEMBL2527940 0.88 TRPV1 (0.52) TRPV1
SCHEMBL2530159 0.87 TRPV1 (0.60) TRPV1
SCHEMBL2532393 0.86 TRPV1 (0.62) TRPV1
SCHEMBL2526774 0.85 TRPV1 (0.62) TRPV1
SCHEMBL2526189 0.84 TRPV1 (0.46) TRPV1
SCHEMBL2524768 0.83 TRPV1 (0.45) TRPV1
SCHEMBL2527167 0.82 TRPV1 (0.61) TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1940821-B1 NOVEL VANILLOID RECEPTOR LIGANDS AND THEIR USE FOR PRODUCING MEDICAMENTS GRUENENTHAL GMBH (DE) 2013-03-20 EP disclosed
EP-2388258-A1 Novel vanilloid receptor ligands and their use for producing medicaments Grünenthal GmbH (DE) 2011-11-23 EP disclosed
US-8038010-B1 Single piece edge protector for curved objects ILLINOIS TOOL WORKS INC. (US) 2011-10-18 US disclosed
EP-1940821-A2 NOVEL VANILLOID RECEPTOR LIGANDS AND THEIR USE FOR PRODUCING MEDICAMENTS Grünenthal GmbH (DE) 2008-07-09 EP disclosed
WO-2007045462-A2 NOVEL VANILLOID RECEPTOR LIGANDS AND THEIR USE FOR PRODUCING MEDICAMENTS Grünenthal GmbH (DE) 2007-04-26 WO disclosed