Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 6/20 | 0.76 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.61 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | GRM8 | O00222 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.40 |
| ▸ | RELA | Q04206 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL367234 | 0.86 | GRM4 (0.74) | GRM4KCNH2FYNGRM8KDR | |
| SCHEMBL366756 | 0.86 | GRM4 (0.74) | GRM4KCNH2FYNGRM8KDR | |
| SCHEMBL369152 | 0.86 | GRM4 (1.00) | GRM4KCNH2FYNGRM8KDR | |
| SCHEMBL369257 | 0.85 | GRM4 (0.73) | GRM4KCNH2FYNGRM8KDR | |
| SCHEMBL366105 | 0.83 | GRM4 (0.70) | GRM4KCNH2FYNGRM8KDR | |
| SCHEMBL370007 | 0.83 | GRM4 (0.70) | GRM4KCNH2FYNGRM8KDR | |
| SCHEMBL369663 | 0.83 | GRM4 (0.73) | GRM4KCNH2FYNGRM8KDR | |
| SCHEMBL370314 | 0.83 | GRM4 (0.70) | GRM4KCNH2FYNGRM8KDR | |
| SCHEMBL365867 | 0.82 | GRM4 (0.71) | GRM4KCNH2FYNGRM8KDR | |
| SCHEMBL370857 | 0.81 | GRM4 (0.66) | GRM4KCNH2FYNGRM8KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9073907-B2 | Thiazoles derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors | ADDEX PHARMA S.A. (CH) | 2015-07-07 | — | — | US | claimed |
| US-20110257179-A1 | NOVEL THIAZOLES DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA SA (CH) | 2011-10-20 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257179-A1 | NOVEL THIAZOLES DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | GRM4, GRM2, GRM1 | GRM4 1/4885KCNH2 1489/4885FYN 3608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.