Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.72 |
| ▸ | FLT3 | P36888 | 11/20 | 0.72 |
| ▸ | JAK2 | O60674 | 10/20 | 0.72 |
| ▸ | LYN | P07948 | 4/20 | 0.72 |
| ▸ | MUSK | O15146 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | PRKCB | P05771 | 1/20 | 0.48 |
| ▸ | ROS1 | P08922 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | FER | P16591 | 1/20 | 0.48 |
| ▸ | PRKACA | P17612 | 1/20 | 0.48 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.48 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.48 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.48 |
| ▸ | MAP3K3 | Q99759 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29492115 | 1.00 | SYK (0.72) | SYKFLT3JAK2LYNMUSK | |
| SCHEMBL25328300 | 1.00 | SYK (0.72) | SYKFLT3JAK2LYNMUSK | |
| SCHEMBL29021321 | 0.84 | SYK (1.00) | SYKFLT3JAK2LYNMUSK | |
| SCHEMBL29492254 | 0.84 | SYK (1.00) | SYKFLT3JAK2LYNMUSK | |
| SCHEMBL29021319 | 0.84 | SYK (1.00) | SYKFLT3JAK2LYNMUSK | |
| SCHEMBL29492156 | 0.82 | SYK (1.00) | SYKFLT3JAK2LYNMUSK | |
| SCHEMBL29021338 | 0.82 | SYK (1.00) | SYKFLT3JAK2LYNMUSK | |
| SCHEMBL29021339 | 0.82 | SYK (1.00) | SYKFLT3JAK2LYNMUSK | |
| SCHEMBL25329124 | 0.76 | SYK (0.51) | SYKFLT3JAK2LYNZAP70 | |
| SCHEMBL25330834 | 0.76 | SYK (0.86) | SYKFLT3JAK2LYNMUSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4217354-A1 | PYRAZOLYL-PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2023-08-02 | — | — | EP | claimed |
| CN-116323595-A | Pyrazolyl-pyrimidine derivatives as kinase inhibitors | 内尔维亚诺医疗科学公司 | 2023-06-23 | — | — | CN | claimed |
| EP-4217354-A1 | PYRAZOLYL-PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2023-08-02 | — | — | EP | disclosed |
| CN-116323595-A | Pyrazolyl-pyrimidine derivatives as kinase inhibitors | 内尔维亚诺医疗科学公司 | 2023-06-23 | — | — | CN | disclosed |