Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.63 |
| ▸ | CDK1 | P06493 | 2/20 | 0.63 |
| ▸ | KDR | P35968 | 2/20 | 0.63 |
| ▸ | CCNK | O75909 | 12/20 | 0.56 |
| ▸ | CDK12 | Q9NYV4 | 12/20 | 0.56 |
| ▸ | CDK7 | P50613 | 12/20 | 0.56 |
| ▸ | CCNH | P51946 | 11/20 | 0.56 |
| ▸ | CCNT1 | O60563 | 10/20 | 0.56 |
| ▸ | CDK9 | P50750 | 10/20 | 0.56 |
| ▸ | MNAT1 | P51948 | 10/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.56 |
| ▸ | CDK2 | P24941 | 8/20 | 0.56 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | JAK1 | P23458 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30524068 | 0.82 | EGFR (0.66) | EGFRCDK1KDRCCNKCDK12 | |
| SCHEMBL20204774 | 0.81 | EGFR (0.67) | EGFRCDK1KDRCCNKCDK12 | |
| SCHEMBL29613510 | 0.81 | EGFR (0.67) | EGFRCDK1KDRCCNKCDK12 | |
| SCHEMBL19054611 | 0.81 | CDK7 (0.64) | EGFRCDK1KDRCCNKCDK12 | |
| SCHEMBL20445168 | 0.79 | CDK1 (0.58) | EGFRCDK1KDRCCNKCDK12 | |
| SCHEMBL17150617 | 0.79 | EGFR (0.72) | EGFRCDK1KDRCCNKCDK12 | |
| SCHEMBL30361949 | 0.79 | EGFR (0.65) | EGFRCDK1KDRCCNKCDK12 | |
| SCHEMBL23625001 | 0.79 | EGFR (0.65) | EGFRCDK1KDRCCNKCDK12 | |
| SCHEMBL29174718 | 0.78 | EGFR (0.57) | EGFRCDK1KDRCDK7CCNH | |
| SCHEMBL24900623 | 0.77 | CDK1 (0.60) | EGFRCDK1KDRCCNKCDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023143482-A1 | 2-AMINOPYRIMIDINE COMPOUND OR SALT, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海辉启生物医药科技有限公司 | 2023-08-03 | — | — | WO | disclosed |