Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2142321 | 0.94 | USP2 (0.49) | USP2SMN1; SMN2RECQLMGLLHPGD | |
| SCHEMBL993522 | 0.89 | USP2 (0.49) | USP2SMN1; SMN2RECQLMGLLHPGD | |
| SCHEMBL18053621 | 0.87 | USP2 (0.59) | USP2SMN1; SMN2RECQLMGLLHPGD | |
| SCHEMBL13116090 | 0.84 | USP2 (0.47) | USP2SMN1; SMN2RECQLHPGDEPHX2 | |
| SCHEMBL996189 | 0.83 | USP2 (0.49) | USP2SMN1; SMN2RECQLMGLLHPGD | |
| Hydrochloric Acid SCHEMBL31401199 | 0.83 | USP2 (0.46) | USP2SMN1; SMN2RECQLEPHX2NAMPT | |
| SCHEMBL4278413 | 0.82 | USP2 (0.54) | USP2SMN1; SMN2RECQLMGLLHPGD | |
| SCHEMBL23611994 | 0.82 | USP2 (0.40) | USP2SMN1; SMN2GPR119KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL1247006 | 0.82 | USP2 (0.48) | USP2SMN1; SMN2RECQLMGLLHPGD | |
| SCHEMBL24803194 | 0.82 | USP2 (0.54) | USP2SMN1; SMN2RECQLMGLLHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4466260-A1 | COMPOUNDS AND THEIR USE IN TREATING CANCER | Astrazeneca AB (SE) | 2024-11-27 | — | — | EP | disclosed |
| CN-118574821-A | Compounds and their use in the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-08-30 | — | — | CN | disclosed |
| WO-2023139199-A1 | COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2023-07-27 | — | — | WO | disclosed |