Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dinoprost. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGFR known ✓ | P43088 | 11/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 3/20 | 1.00 |
| ▸ | PTGER3 | P43115 | 3/20 | 1.00 |
| ▸ | PTGER1 | P34995 | 2/20 | 1.00 |
| ▸ | PTGER4 | P35408 | 1/20 | 1.00 |
| ▸ | PTGDR | Q13258 | 1/20 | 1.00 |
| ▸ | SLCO2A1 | Q92959 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 0.85 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.85 |
| ▸ | TSHR | P16473 | 1/20 | 0.79 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.79 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.79 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.79 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.79 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.79 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.79 |
| ▸ | MEN1 | O00255 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dinoprost SCHEMBL64966 | 1.00 | PTGFR (1.00) | PTGFRALDH1A1LMNATBXA2RPTGER3 | |
| Dinoprost SCHEMBL19409794 | 1.00 | PTGFR (1.00) | PTGFRALDH1A1LMNATBXA2RPTGER3 | |
| Dinoprost SCHEMBL4916605 | 1.00 | PTGFR (1.00) | PTGFRALDH1A1LMNATBXA2RPTGER3 | |
| Dinoprost SCHEMBL18027080 | 1.00 | PTGFR (1.00) | PTGFRALDH1A1LMNATBXA2RPTGER3 | |
| Dinoprost SCHEMBL13905976 | 1.00 | PTGFR (1.00) | PTGFRALDH1A1LMNATBXA2RPTGER3 | |
| Dinoprost SCHEMBL23352547 | 1.00 | PTGFR (1.00) | PTGFRALDH1A1LMNATBXA2RPTGER3 | |
| Dinoprost SCHEMBL1650065 | 1.00 | PTGFR (1.00) | PTGFRALDH1A1LMNATBXA2RPTGER3 | |
| Dinoprost SCHEMBL23352774 | 1.00 | PTGFR (1.00) | PTGFRALDH1A1LMNATBXA2RPTGER3 | |
| Dinoprost SCHEMBL22085922 | 1.00 | PTGFR (1.00) | PTGFRALDH1A1LMNATBXA2RPTGER3 | |
| Dinoprost SCHEMBL4301844 | 1.00 | PTGFR (1.00) | PTGFRALDH1A1LMNATBXA2RPTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4218759-A2 | COMBINATION THERAPY | Aerie Pharmaceuticals, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |