Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 6/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.51 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MLYCD | O95822 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL109091 | 0.95 | PHGDH (0.65) | PHGDHHPGDAKR1C3TSHRL3MBTL1 | |
| SCHEMBL2040124 | 0.87 | PHGDH (0.55) | PHGDHHPGDAKR1C3TSHRL3MBTL1 | |
| SCHEMBL29950978 | 0.83 | HPGD (0.57) | HPGDALDH1A1SMN1; SMN2MAPK1HTT | |
| SCHEMBL10720943 | 0.83 | PHGDH (0.81) | PHGDHHPGDAKR1C3TSHRL3MBTL1 | |
| SCHEMBL950365 | 0.80 | HPGD (0.64) | HPGDTSHRALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL204078 | 0.80 | HPGD (0.70) | HPGDTSHRL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL12960648 | 0.79 | PHGDH (0.65) | PHGDHHPGDAKR1C3TSHRL3MBTL1 | |
| SCHEMBL258027 | 0.78 | HPGD (0.74) | HPGDTSHRL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL28296651 | 0.78 | HPGD (0.86) | PHGDHHPGDAKR1C3TSHRL3MBTL1 | |
| SCHEMBL8123 | 0.77 | TSHR (0.60) | HPGDTSHRL3MBTL1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8034940-B2 | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-10-11 | — | — | US | disclosed |