Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 18/20 | 0.62 |
| ▸ | JAK2 | O60674 | 15/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21751129 | 0.92 | JAK1 (0.61) | JAK1JAK2 | |
| SCHEMBL30018516 | 0.92 | JAK1 (0.61) | JAK1JAK2 | |
| SCHEMBL20400706 | 0.91 | JAK2 (0.62) | JAK1JAK2 | |
| SCHEMBL30018202 | 0.91 | JAK2 (0.62) | JAK1JAK2 | |
| SCHEMBL23522368 | 0.86 | JAK1 (0.65) | JAK1JAK2 | |
| SCHEMBL20400701 | 0.83 | JAK2 (0.63) | JAK1JAK2 | |
| SCHEMBL30018494 | 0.83 | JAK2 (0.63) | JAK1JAK2 | |
| SCHEMBL23130598 | 0.83 | JAK2 (0.53) | JAK1JAK2 | |
| SCHEMBL23130600 | 0.81 | JAK2 (0.65) | JAK1JAK2 | |
| SCHEMBL30092437 | 0.81 | JAK2 (0.65) | JAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219470-A1 | JAK1 SELECTIVE INHIBITORS | Astrazeneca AB (SE) | 2023-08-02 | — | — | EP | disclosed |
| EP-3571192-B1 | JAK1 SELECTIVE INHIBITORS | ASTRAZENECA AB (SE) | 2022-11-30 | — | — | EP | disclosed |