Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 20/20 | 0.86 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.73 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.73 |
| ▸ | BCL2L2 | Q92843 | 2/20 | 0.73 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.73 |
| ▸ | NSD2 | O96028 | 1/20 | 0.72 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.72 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.72 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.72 |
| ▸ | BID | P55957 | 1/20 | 0.72 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.72 |
| ▸ | ASPH | Q12797 | 1/20 | 0.72 |
| ▸ | BAD | Q92934 | 1/20 | 0.72 |
| ▸ | NSD1 | Q96L73 | 1/20 | 0.72 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30485139 | 1.00 | BCL2 (0.86) | BCL2BCL2L1MCL1BCL2L2TMEM97 | |
| SCHEMBL25333332 | 1.00 | BCL2 (0.86) | BCL2BCL2L1MCL1BCL2L2TMEM97 | |
| SCHEMBL31450908 | 0.95 | BCL2 (0.90) | BCL2BCL2L1MCL1BCL2L2TMEM97 | |
| SCHEMBL26647979 | 0.95 | BCL2 (0.90) | BCL2BCL2L1MCL1BCL2L2TMEM97 | |
| SCHEMBL26648486 | 0.93 | BCL2 (0.89) | BCL2BCL2L1MCL1BCL2L2TMEM97 | |
| SCHEMBL31450997 | 0.93 | BCL2 (0.89) | BCL2BCL2L1MCL1BCL2L2TMEM97 | |
| SCHEMBL31450966 | 0.93 | BCL2 (0.89) | BCL2 | |
| SCHEMBL31450969 | 0.93 | BCL2 (0.89) | BCL2 | |
| SCHEMBL26647805 | 0.93 | BCL2 (0.89) | BCL2 | |
| SCHEMBL1702331 | 0.92 | BCL2 (1.00) | BCL2BCL2L1MCL1BCL2L2NSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4461730-A1 | PROTEIN DEGRADERS DEVELOPED ON BASIS OF BCL-2 FAMILY PROTEIN LIGAND COMPOUNDS AND USE THEREOF | Shanghaitech University (CN) | 2024-11-13 | — | — | EP | disclosed |
| WO-2023131118-A1 | PROTEIN DEGRADERS DEVELOPED ON BASIS OF BCL-2 FAMILY PROTEIN LIGAND COMPOUNDS AND USE THEREOF | 上海科技大学 | 2023-07-13 | — | — | WO | disclosed |