Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.67 |
| ▸ | JAK3 | P52333 | 8/20 | 0.67 |
| ▸ | EGFR | P00533 | 5/20 | 0.67 |
| ▸ | CDC7 | O00311 | 1/20 | 0.61 |
| ▸ | PLK4 | O00444 | 1/20 | 0.61 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.61 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.61 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.61 |
| ▸ | INSR | P06213 | 1/20 | 0.61 |
| ▸ | LCK | P06239 | 1/20 | 0.61 |
| ▸ | FYN | P06241 | 1/20 | 0.61 |
| ▸ | CDK1 | P06493 | 1/20 | 0.61 |
| ▸ | RET | P07949 | 1/20 | 0.61 |
| ▸ | ROS1 | P08922 | 1/20 | 0.61 |
| ▸ | SRC | P12931 | 1/20 | 0.61 |
| ▸ | FER | P16591 | 1/20 | 0.61 |
| ▸ | PRKACA | P17612 | 1/20 | 0.61 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.61 |
| ▸ | CDK2 | P24941 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28399962 | 1.00 | JAK2 (0.67) | JAK2JAK3EGFRCDC7PLK4 | |
| SCHEMBL4826137 | 1.00 | JAK2 (0.67) | JAK2JAK3EGFRCDC7PLK4 | |
| SCHEMBL4827998 | 0.93 | EGFR (0.77) | JAK2JAK3EGFRCDC7PLK4 | |
| SCHEMBL13860290 | 0.93 | EGFR (0.77) | JAK2JAK3EGFRCDC7PLK4 | |
| SCHEMBL27586636 | 0.93 | EGFR (0.77) | JAK2JAK3EGFRCDC7PLK4 | |
| SCHEMBL5802174 | 0.93 | JAK2 (0.67) | JAK2JAK3EGFRCDC7PLK4 | |
| SCHEMBL3782927 | 0.90 | EGFR (0.63) | JAK2JAK3EGFRCDC7PLK4 | |
| SCHEMBL17235861 | 0.87 | EGFR (0.88) | JAK2JAK3EGFRKDRJAK1 | |
| SCHEMBL30082483 | 0.87 | EGFR (0.88) | JAK2JAK3EGFRKDRJAK1 | |
| SCHEMBL17267791 | 0.87 | EGFR (0.88) | JAK2JAK3EGFRKDRJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115485281-B | FGFR and mutation inhibitor thereof, and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2023-11-21 | — | — | CN | disclosed |
| WO-2023143514-A1 | PROPYLENE KETONE-CONTAINING BIOINHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF | 上海翰森生物医药科技有限公司 | 2023-08-03 | — | — | WO | disclosed |
| CN-116514806-A | Biological inhibitor containing acrylketone, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2023-08-01 | — | — | CN | disclosed |
| EP-4169922-A1 | FGFR AND MUTATION INHIBITOR THEREOF, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2023-04-26 | — | — | EP | disclosed |
| CN-115485281-A | FGFR and mutation inhibitor thereof, and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2022-12-16 | — | — | CN | disclosed |
| CN-113260618-A | Dimethoxybenzene compound analogue, method for analyzing compound and standard substance of compound | 大鹏药品工业株式会社 | 2021-08-13 | — | — | CN | disclosed |