SCHEMBL25335347

SCHEMBL25335347

O=C(O)[C@@H]1CC(O)(C(F)(F)F)CN1C(=O)O

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.33
GRM2 Q14416 1/20 0.33
GRM3 Q14832 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21075266 0.86 ATM (0.46) ATMGRM2GRM3
SCHEMBL17428818 0.86 ATM (0.46) ATMGRM2GRM3
SCHEMBL19083907 0.83 ATM (0.33) ATM
SCHEMBL30484715 0.83 ATM (0.32) ATM
SCHEMBL20307078 0.82 PIK3CD (0.34) ATM
SCHEMBL27245076 0.82 GRM2 (0.33) ATMGRM2GRM3
SCHEMBL27245216 0.82 GRM2 (0.33) ATMGRM2GRM3
SCHEMBL27244942 0.82 GRM2 (0.33) ATMGRM2GRM3
SCHEMBL20446514 0.80 HSD17B10 (0.39) ATM
SCHEMBL19066055 0.80 HSD17B10 (0.39) ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023183405-A2 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS ALEXION PHARMACEUTICALS, INC. (US) 2023-09-28 WO disclosed
WO-2023133174-A1 PROTEASE INHIBITORS FOR TREATING OR PREVENTING CORONAVIRUS INFECTION MERCK SHARP & DOHME LLC (US) 2023-07-13 WO disclosed