Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 7/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | NRAS | P01111 | 2/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | NEK2 | P51955 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24231461 | 0.93 | FLT3 (0.44) | FLT3FGFR3KDRCCNT1NRAS | |
| SCHEMBL29373046 | 0.93 | FLT3 (0.44) | FLT3FGFR3KDRCCNT1NRAS | |
| SCHEMBL24231733 | 0.92 | FGFR3 (0.40) | FLT3FGFR3KDRCCNT1NRAS | |
| SCHEMBL24231649 | 0.89 | FLT3 (0.48) | FLT3CCNT1NRASIRAK4USP30 | |
| SCHEMBL25337713 | 0.87 | FLT3 (0.40) | FLT3KDRNRASIRAK4 | |
| SCHEMBL25997411 | 0.86 | FLT3 (0.47) | FLT3FGFR3KDRCCNT1NRAS | |
| SCHEMBL29372530 | 0.86 | USP30 (0.48) | FLT3FGFR3KDRCCNT1NRAS | |
| SCHEMBL24231566 | 0.86 | USP30 (0.48) | FLT3FGFR3KDRCCNT1NRAS | |
| SCHEMBL24231729 | 0.85 | USP30 (0.43) | FLT3FGFR3KDRCCNT1IRAK4 | |
| SCHEMBL24231697 | 0.85 | USP30 (0.45) | FLT3FGFR3KDRCCNT1NRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023150601-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-08-10 | — | — | WO | disclosed |
| WO-2023150601-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-08-10 | — | — | WO | disclosed |